Identification of Target Proteins for Promoting Nuclear Envelope Rupture in Cancer Cells

The nuclear envelope separates and protects DNA from the cytoplasm. In cancer cells, frequent morphological abnormalities transient rupture of membrane promote damage malignancy. However, instability, acting as a tumor-promotion factor, can be viewed fatal weakness cells. Although exact mechanism is not clear, it known that loss tumor suppressor gene TP53 involved in instability this study, we demonstrate inhibition NUP93, which subunit pore complex, induces cell death by enhancing instability. RNA interference (RNAi) inhibiting NUP93 expression human line RPE1 caused rupture, damage, leading to death. Under condition was simultaneously suppressed with were significantly increased. Conversely, slightly decreased. decrease may ascribed fact induction apoptosis damage. We speculate amplification induce cell-specific synthetic lethality context TP53-independent Moreover, our results suggest proteins promising targets for development lethal anticancer drugs.